5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid

Base Information

• Chemical Name: 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid
• CAS No.: 1084949-39-2
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₄N₆O
• Molecular Weight: 502.496

Synonyms:5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid

Chemical Property of 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid

Chemical Property:

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Technology Process of 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid

There total 11 articles about 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-butyl-2-hydroxymethyl-1-[[2'-[[N-(2-chlorotrityl)]tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole (1084949-70-1) + trifluoroacetic acid (76-05-1) → 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid (1084949-39-2)

Guidance literature:

With triethylsilane; In dichloromethane; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1007/s10822-010-9371-3

Reference yield: 75.0%

5-butyl-2-hydroxymethyl-1-[[2'-[(N-benzyl)tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole trifluoroacetic acid → 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid (1084949-39-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃; for 24h; regioselective reaction;

DOI:10.1007/s10822-010-9371-3

Reference yield:

3-(triphenylmethyl)-5-butylimidazole (1084949-58-5) → 5-butyl-2-hydroxymethyl-1-[[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole trifluoroacetic acid (1084949-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 24 h / 20 °C / Inert atmosphere

2: triethylsilane / dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide / 8 h / 140 °C

4: palladium 10% on activated carbon; hydrogen / acetic acid / 24 h / 20 °C

With triethylsilane; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1007/s10822-010-9371-3

upstream raw materials:

5-butyl-2-hydroxymethyl-1-[[2'-[[N-(2-chlorotrityl)]tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole

trifluoroacetic acid

3-(triphenylmethyl)-5-butylimidazole

Br^(1-)*C₅₉H₅₁N₆⁽¹⁺⁾

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