Technology Process of 4-hydroxy-2,5-dimethoxybenzoic acid
There total 3 articles about 4-hydroxy-2,5-dimethoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; water;
at 80 ℃;
for 15h;
Inert atmosphere;
DOI:10.1021/ja206339s
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dihydrogen peroxide; potassium hydroxide / methanol; water / 1.5 h / 65 °C / Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos / 1,4-dioxane; water / 15 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); dihydrogen peroxide; potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; methanol; water;
DOI:10.1021/ja206339s
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bromine; acetic acid / 48 h / 23 °C / Inert atmosphere
2: dihydrogen peroxide; potassium hydroxide / methanol; water / 1.5 h / 65 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide; tert-butyl XPhos / 1,4-dioxane; water / 15 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); dihydrogen peroxide; bromine; acetic acid; potassium hydroxide; tert-butyl XPhos;
In
1,4-dioxane; methanol; water;
DOI:10.1021/ja206339s
