5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

Base Information

Chemical Name:5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide
CAS No.:1056416-83-1
Molecular Formula:C₂₆H₂₁Cl₂N₃O₃
Molecular Weight:494.377
Hs Code.:

Synonyms:5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

Chemical Property:

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Technology Process of 5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

There total 12 articles about 5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1056418-83-7
5-chloro-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1056416-83-1
5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 95 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.10.045

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 1056416-83-1
5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water / N,N-dimethyl-formamide / 3 h / 0 - 25 °C

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water / N,N-dimethyl-formamide / 2.5 h / 100 °C

3: potassium hydroxide / tetrahydrofuran; methanol / 1.5 h / 25 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2.5 h / 25 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: |Suzuki-Miyaura Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.10.045

Reference yield:

: C₁₇H₁₀Cl₂N₂O₂

: 5763-61-1
3,4-dimethoxybenzylamine

: 1056416-83-1
5-(3,5-dichlorophenyl)-N-(3,4-dimethoxybenzyl)-2,3'-bipyridine-3-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2013.10.045