2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

Base Information

Chemical Name:2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester
CAS No.:1026363-11-0
Molecular Formula:C₅₄H₅₆N₂O₈
Molecular Weight:861.047
Hs Code.:

2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-<i>tert</i>-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid <i>tert</i>-butyl ester

Synonyms:2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

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Chemical Property of 2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

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Technology Process of 2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

There total 11 articles about 2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 841275-43-2
2-tert-butoxycarbonylamino-3-[3-(4-iodomethyl-phenoxy)-4-methoxy-phenyl]-propionic acid benzhydryl ester

: 1026363-11-0
2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: With potassium hydroxide; chiral phase-transfer catalyst; In toluene; at 20 ℃; for 18h;
DOI:10.1055/s-2004-835623

Reference yield:

: 1195-09-1
5-methyl-2-methoxyphenol

: 1026363-11-0
2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: CuO; K₂CO₃; pyridine / Heating

2: NaBH₄ / methanol / 20 °C

3: aq. HCl / ethyl acetate / 20 °C

4: 53 percent / NBS; AIBN / CCl₄ / Heating; irradiation

5: 87 percent / aq. KOH / chiral phase transfer catalyst / toluene / 20 °C

6: aq. citric acid / tetrahydrofuran / 20 °C

7: NaHCO₃ / dioxane / 20 °C

8: NaI / acetone / 20 °C

9: aq. KOH / chiral phase-transfer catalyst / toluene / 18 h / 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; potassium carbonate; citric acid; sodium iodide; copper(II) oxide; chiral phase transfer catalyst; chiral phase-transfer catalyst; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethyl acetate; acetone; toluene; 1: Ullmann coupling / 8: Finklestein reaction;
DOI:10.1055/s-2004-835623

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026363-11-0
2-(benzhydrylidene-amino)-3-{4-[5-(2-benzhydryloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-phenyl}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / dioxane / 20 °C

2: NaI / acetone / 20 °C

3: aq. KOH / chiral phase-transfer catalyst / toluene / 18 h / 20 °C

With potassium hydroxide; sodium hydrogencarbonate; sodium iodide; chiral phase-transfer catalyst; In 1,4-dioxane; acetone; toluene; 2: Finklestein reaction;
DOI:10.1055/s-2004-835623