3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Base Information

Chemical Name:3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
CAS No.:1324009-96-2
Molecular Formula:C₁₇H₉F₃N₄O₃
Molecular Weight:374.279
Hs Code.:

Synonyms:3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

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Chemical Property of 3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

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Technology Process of 3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

There total 7 articles about 3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.6%

: 1324009-97-3
4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzonitrile

: 1324009-96-2
3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 20 ℃;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1324009-96-2
3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 16 h / 120 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2.2: 5 - 20 °C

3.1: boron tribromide / dichloromethane / -10 - 20 °C

3.2: 3 h / Reflux

4.1: hydrogenchloride / 1,4-dioxane; water / 70 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

5.2: 2 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 20 °C

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; boron tribromide; di(n-butyl)tin oxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 22744-12-3
[4-(methoxycarbonyl)phenyl]acetic acid

: 1324009-96-2
3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

1.2: 5 - 20 °C

2.1: boron tribromide / dichloromethane / -10 - 20 °C

2.2: 3 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane; water / 70 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

4.2: 2 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 20 °C

With hydrogenchloride; oxalyl dichloride; trimethylsilylazide; boron tribromide; di(n-butyl)tin oxide; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; toluene;