(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

Base Information

Chemical Name:(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one
CAS No.:1422452-66-1
Molecular Formula:C₂₅H₂₅ClO₄
Molecular Weight:424.924
Hs Code.:

Synonyms:(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

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Chemical Property of (E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

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Technology Process of (E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

There total 7 articles about (E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: 1422452-54-7
(E)-3-(3-(4-chlorophenyl)-3-oxoprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

: 1422452-66-1
(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

Guidance literature:: (E)-3-(3-(4-chlorophenyl)-3-oxoprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one; With cerium(III) chloride heptahydrate; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2012.11.007

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1422452-66-1
(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 5 h / pH 7 - 8

3.1: dichloromethane / 20 °C

4.1: cerium(III) chloride heptahydrate / methanol; tetrahydrofuran / 0.17 h / 20 °C

4.2: 1 h / 0 - 20 °C

With cerium(III) chloride heptahydrate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 3.1: |Wittig Olefination;
DOI:10.1016/j.ejmech.2012.11.007

Reference yield:

: 699-83-2
2,6-dihydroxylacetophenone

: 1422452-66-1
(E)-3-(3-(4-chlorophenyl)-3-hydroxyprop-1-enyl)-5-(cyclohexylmethoxy)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; sodium iodide / water; acetonitrile / Reflux

2.1: trichlorophosphate / 20 °C

3.1: dichloromethane / 20 °C

4.1: cerium(III) chloride heptahydrate / methanol; tetrahydrofuran / 0.17 h / 20 °C

4.2: 1 h / 0 - 20 °C

With cerium(III) chloride heptahydrate; potassium carbonate; sodium iodide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 3.1: |Wittig Olefination;
DOI:10.1016/j.ejmech.2012.11.007