(6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate

Base Information

• Chemical Name: (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate
• CAS No.: 1248361-39-8
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 1248361-39-8.mol

Synonyms:(6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate

Chemical Property of (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate

There total 2 articles about (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-tert-butyl-5-methoxy-6-methyl-2-phenylpyrimidine-1-oxide (1248361-18-3) + acetic anhydride (108-24-7) → (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate (1248361-39-8) + 4-tert-butyl-6-ethyl-5-methoxy-2-phenylpyrimidine

Guidance literature:

at 120 ℃; for 3h; Sealed tube;

DOI:10.1055/s-0040-1706020

Reference yield:

C16H21NO3 → (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate (1248361-39-8) + 4-tert-butyl-6-ethyl-5-methoxy-2-phenylpyrimidine

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol / 24 h / 20 °C

2: 3 h / 120 °C / Sealed tube

With hydroxylamine hydrochloride; In methanol;

DOI:10.1055/s-0040-1706020

Reference yield: 85.0%

(6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methyl acetate (1248361-39-8) → (6-tert-butyl-5-methoxy-2-phenylpyrimidin-4-yl)methanol

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 3h;

DOI:10.1055/s-0040-1706020

upstream raw materials:

4-tert-butyl-5-methoxy-6-methyl-2-phenylpyrimidine-1-oxide

acetic anhydride