N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide
CAS No.:1206771-68-7
Molecular Formula:C₂₄H₂₈N₂O₅S
Molecular Weight:456.563
Hs Code.:

Synonyms:N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

Suppliers and Price of N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

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Chemical Property of N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

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Technology Process of N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

There total 9 articles about N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1206774-48-2
N-[4-[(5-bromo-3-tert-butyl-2-methoxyphenyl)methoxy]phenyl]methanesulfonamide

: 951655-49-5
(2-oxo-1,2-dihydropyridin-3-yl)boronic acid

: 1206771-68-7
N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; dichloromethane; at 115 ℃; for 0.583333h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm401266k

Reference yield:

: 2-oxo-1,2-dihydropyridine-3-boronic acid

: 1206774-48-2
N-[4-[(5-bromo-3-tert-butyl-2-methoxyphenyl)methoxy]phenyl]methanesulfonamide

: 1206771-68-7
N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

Guidance literature:: With sodium carbonate; Pd(PPh₃)4; In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: C₁₂H₁₇BrO₂

: 1206771-68-7
N-[4-[[3-tert-butyl-2-methoxy-5-(2-oxo-1H-pyridin-3-yl)phenyl]methoxy]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: potassium carbonate / 2 h / 50 °C / Inert atmosphere

3: ammonium chloride; iron / methanol; water / 1 h / Inert atmosphere; Reflux

4: pyridine / 3.5 h / 0 - 20 °C / Inert atmosphere

5: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.58 h / 115 °C / Inert atmosphere; Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; iron; sodium carbonate; potassium carbonate; ammonium chloride; triphenylphosphine; In methanol; dichloromethane; water;
DOI:10.1021/jm401266k