furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

Base Information

Chemical Name:furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone
CAS No.:1313816-93-1
Molecular Formula:C₂₀H₂₂N₂O₄
Molecular Weight:354.406
Hs Code.:

Synonyms:furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

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Chemical Property of furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

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Technology Process of furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

There total 7 articles about furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 527-69-5
2-furancarbonyl chloride

: 1313816-86-2
3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane

: 1313816-93-1
furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1313816-93-1
furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene; tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Cooling with ice

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1313816-84-0
3-methylaminomethyl-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

: 1313816-93-1
furan-2-yl-[3-[(N-benzyloxycarbonyl-N-methyl)aminomethyl]-2-azabicyclo[3.1.0]hex-2-yl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / toluene; tetrahydrofuran / 16 h / 20 °C / Cooling with ice

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C / Cooling with ice

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;