methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

Base Information

Chemical Name:methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate
CAS No.:1257424-08-0
Molecular Formula:C₂₀H₂₁ClFN₅O₆S
Molecular Weight:513.934
Hs Code.:

Synonyms:methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

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Chemical Property of methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

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Technology Process of methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

There total 10 articles about methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 151827-83-7
methyl N-(2-bromomethylphenyl)-N-methoxy-carbamate

: 1257424-14-8
C₁₂H₁₄ClFN₄O₇S₃

: 1257424-08-0
methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3390/molecules15129024

Reference yield:

: 151827-82-6
methyl N-(2-methylphenyl)-N-methoxy-carbamate

: 1257424-08-0
methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile)

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.3390/molecules15129024

Reference yield:

: 112006-20-9
C₉H₈ClFN₂O₂

: 1257424-08-0
methyl 2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl(methoxy)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / Reflux

2: sulfuric acid; nitric acid / 0 - 20 °C

3: iron; ammonium chloride / ethanol; water / Reflux

4: triethylamine / dichloromethane / 0 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; diphenyl phosphoryl azide; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Schmidt reaction;
DOI:10.3390/molecules15129024