(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

Base Information

Chemical Name:(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine
CAS No.:139305-64-9
Molecular Formula:C₂₇H₂₄F₂N₂O₂
Molecular Weight:446.497
Hs Code.:

(E)-1-(3-Fluoro-6,11-dihydrodibenz<b,e>oxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

Synonyms:(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

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Chemical Property of (E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

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Technology Process of (E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

There total 7 articles about (E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 459-32-5
(E)-4-fluorocinnamic acid

: 139305-63-8
1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)piperazine

: 139305-64-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1248/cpb.39.2564

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 139305-64-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / 1 h / 200 °C

2: 92 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: 97 percent / NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: CH₂Cl₂ / 2 h / Ambient temperature

6: 66 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1248/cpb.39.2564

Reference yield:

: 35535-79-6
sodium m-fluoro phenoxide

: 139305-64-9
(E)-1-(3-Fluoro-6,11-dihydrodibenzoxepin-11-yl)-4-<3-(4-fluorophenyl)-1-oxo-2-propenyl>piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / 1 h / 200 °C

2: 92 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: 97 percent / NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: CH₂Cl₂ / 2 h / Ambient temperature

6: 66 percent / 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic anhydride; In methanol; dichloromethane;
DOI:10.1248/cpb.39.2564