4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

Base Information

Chemical Name:4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol
CAS No.:865235-97-8
Molecular Formula:C₂₄H₂₄F₆O₂
Molecular Weight:458.444
Hs Code.:

Synonyms:4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

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Chemical Property of 4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

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Technology Process of 4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

There total 4 articles about 4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 865235-91-2
4-[1-ethyl-1-(4-ethynyl-3-methylphenyl)-propyl]-2-methylphenol

: 684-16-2
Hexafluoroacetone

: 865235-97-8
4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

Guidance literature:: 4-[1-ethyl-1-(4-ethynyl-3-methylphenyl)-propyl]-2-methylphenol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;

Hexafluoroacetone; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.11.029

Reference yield:

: 865235-89-8
trifluoromethanesulfonic acid 4-[1-ethyl-1-(4-hydroxy-3-methylphenyl)-propyl]-2-methylphenyl ester

: 865235-97-8
4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 110 °C

1.2: pH 7

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

3.2: 0.5 h / 0 °C

With n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; acetonitrile;

Reference yield:

: 55041-27-5
3,3-bis[4-hydroxy-3-methylphenyl]pentane

: 865235-97-8
4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1 h / 0 °C

2.1: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 110 °C

2.2: pH 7

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

4.2: 0.5 h / 0 °C

With pyridine; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;