3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

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Chemical Name:3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid
CAS No.:632624-64-7
Molecular Formula:C₂₈H₂₃BrF₂N₂O₅S
Molecular Weight:617.468
Hs Code.:

Synonyms:3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

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Chemical Property of 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

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Technology Process of 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

There total 6 articles about 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid methyl ester

: 632624-64-7
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

Guidance literature:: With sodium hydroxide; water; In methanol; at 60 ℃; for 1h;

Reference yield:

: 632626-89-2
3-(1,1-dioxo-1/⁶-isothiazolidin-2-yl)-5-nitrobenzoic acid methyl ester

: 632624-64-7
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 760.05 Torr

2: powdered 4 Å molecular sieves / toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 18 h / 180 °C

3: sodium hydroxide; water / methanol / 1 h / 60 °C

With sodium hydroxide; water; hydrogen; palladium 10% on activated carbon; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

: 632626-90-5
3-amino-5-(1,1-dioxo-1/⁶-isothiazolidin-2-yl)benzoic acid methyl ester

: 632624-64-7
3-{2-[5-bromo-2-(2,4-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-(1,1-dioxo-1/6-isothiazolidin-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: powdered 4 Å molecular sieves / toluene-4-sulfonic acid / 1-methyl-pyrrolidin-2-one / 18 h / 180 °C

2: sodium hydroxide; water / methanol / 1 h / 60 °C

With sodium hydroxide; water; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; methanol;