Technology Process of (2R,3R)-3'-O-(tert-butyldimethylsilyl)-5,7,4'-tri-O-benzyl-epi-catechin
There total 12 articles about (2R,3R)-3'-O-(tert-butyldimethylsilyl)-5,7,4'-tri-O-benzyl-epi-catechin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-Selectride;
In
tetrahydrofuran;
at -78 ℃;
for 8h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ol3016463
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2: diisobutylaluminium hydride / toluene / 2 h / -78 °C / Inert atmosphere
3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere
4: L-Selectride / tetrahydrofuran / 8 h / -78 °C / Inert atmosphere
With
1H-imidazole; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol3016463
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 4 h / 20 - 50 °C / Inert atmosphere
2: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
3: diisobutylaluminium hydride / toluene / 2 h / -78 °C / Inert atmosphere
4: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere
5: L-Selectride / tetrahydrofuran / 8 h / -78 °C / Inert atmosphere
With
1H-imidazole; pyridinium p-toluenesulfonate; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol3016463
