1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one

Base Information

Chemical Name:1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one
CAS No.:64967-16-4
Molecular Formula:C₉H₁₁FN₂O₅
Molecular Weight:246.195
Hs Code.:
Nikkaji Number:J448.720F
Wikidata:Q76009759
Mol file:64967-16-4.mol

Synonyms:1 beta-D-ribofuranosyl-5-fluoropyrimidin-2(1H)-one;5-F-zebularine;5-fluoro-zebularine;5-fluoropyrimidin-2-one beta-ribofuranoside;5-fluoropyrimidin-2-one ribonucleoside;5-fluoropyrimidin-2-one riboside;5-fluorozebularine;5-FPOR

Suppliers and Price of 1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one

Chemical Property:

Vapor Pressure:1.31E-10mmHg at 25°C
Boiling Point:465.2°C at 760 mmHg
Flash Point:235.1°C
PSA：104.81000
Density:1.82g/cm³
LogP:-2.00610
XLogP3:-1.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:246.06519962
Heavy Atom Count:17
Complexity:386

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=NC(=O)N1C2C(C(C(O2)CO)O)O)F
Isomeric SMILES:C1=C(C=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)F

Technology Process of 1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one

There total 3 articles about 1beta-D-Ribofuranosyl-5-fluoropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 35068-60-1
1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5-fluoropyrimidin-2(1H)-one

: 64967-16-4,863506-86-9
5-Fluorozebularine

Guidance literature:: With ammonia; In methanol; at 8 ℃;
DOI:10.1021/jm00115a017

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 64967-16-4,863506-86-9
5-Fluorozebularine

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₄ / 1,2-dichloro-ethane / 18 h / Ambient temperature

2: 57 percent / ammonia / methanol / 8 °C

With ammonia; tin(IV) chloride; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00115a017