N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

Base Information

Chemical Name:N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine
CAS No.:1204331-20-3
Molecular Formula:C₂₂H₂₆N₄O₅S*ClH
Molecular Weight:494.999
Hs Code.:

Synonyms:N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

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Chemical Property of N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

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Technology Process of N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

There total 2 articles about N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1204331-19-0
4-{2-methanesulfonyl-4-[N-(carbobenzyloxy)guanidinocarbonyl]phenyl}piperidine-1-carboxylic acid tert-butyl ester

: 1204331-20-3
N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

Guidance literature:: 4-{2-methanesulfonyl-4-[N-(carbobenzyloxy)guanidinocarbonyl]phenyl}piperidine-1-carboxylic acid tert-butyl ester; With 10% Pd/C; hydrogen; In ethanol; N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

With hydrogenchloride; In water;
DOI:10.1021/jm300601d

Reference yield:

: 154117-61-0
methyl 3-methylsulfonyl-4-bromobenzoate

: 1204331-20-3
N-(3-methanesulfonyl-4-piperidine-4-yl-benzoyl)-N?'-(carbobenzyloxy)guanidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 170 °C / Microwave irradiation

2.1: hydrogen; acetic acid; platinum(IV) oxide / Inert atmosphere

3.1: lithium hydroxide monohydrate / methanol; water / 40 °C

3.2: pH 5

4.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

4.2: 20 °C

5.1: hydrogen; 10% Pd/C / ethanol; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 10% Pd/C; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1021/jm300601d