(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

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Chemical Name:(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate
CAS No.:890155-20-1
Molecular Formula:C₂₁H₂₀ClFN₂O₆S
Molecular Weight:482.917
Hs Code.:
Mol file:890155-20-1.mol

Synonyms:(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

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Chemical Property of (1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate Edit

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Technology Process of (1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

There total 2 articles about (1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 340722-43-2
(6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid

: 6531-13-1,58287-18-6,99531-06-3,96156-72-8
(S)-1-[4-nitrophenyl]ethanol

: 890155-20-1
(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 7h;
DOI:10.1248/cpb.54.58

Reference yield:

: 243983-70-2,243984-10-3
ethyl (6RS)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

: 890155-20-1
(1'R)-1'-(4-nitrophenyl)ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / Ba(OH)2*8H₂O / acetonitrile / 1 h / 60 °C

2: 32 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 7 h

With barium dihydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1248/cpb.54.58