piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

Base Information

Chemical Name:piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone
CAS No.:940830-05-7
Molecular Formula:C₁₆H₁₈N₂OS
Molecular Weight:286.398
Hs Code.:

Synonyms:piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

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Chemical Property of piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

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Technology Process of piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

There total 5 articles about piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-89-4
piperidine

: 17228-99-8
2-(p-tolyl)thiazole-4-carboxylic acid

: 940830-05-7
piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

Guidance literature:: 2-(p-tolyl)thiazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.5h;

piperidine; In acetonitrile; for 24h;
DOI:10.5562/cca1939

Reference yield:

: 2362-62-1
4-methylthiobenzamide

: 940830-05-7
piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / Reflux

2.1: sulfuric acid / water / Reflux

3.1: manganese(IV) oxide / chloroform / 12 h / 20 °C

4.1: dihydrogen peroxide; potassium hydroxide / methanol; water / 0.5 h / 65 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.5 h / 20 °C

5.2: 24 h

With manganese(IV) oxide; sulfuric acid; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; chloroform; water; toluene; acetonitrile;
DOI:10.5562/cca1939

Reference yield:

: 104-85-8
para-methylbenzonitrile

: 940830-05-7
piperidin-1-yl(2-p-tolylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium sulfide / N,N-dimethyl-formamide / 5 h / 200 °C

2.1: toluene / 2 h / Reflux

3.1: sulfuric acid / water / Reflux

4.1: manganese(IV) oxide / chloroform / 12 h / 20 °C

5.1: dihydrogen peroxide; potassium hydroxide / methanol; water / 0.5 h / 65 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.5 h / 20 °C

6.2: 24 h

With manganese(IV) oxide; ammonium sulfide; sulfuric acid; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.5562/cca1939