N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

Base Information

Chemical Name:N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide
CAS No.:1242163-33-2
Molecular Formula:C₁₈H₁₈N₄O₄S₂
Molecular Weight:418.497
Hs Code.:

Synonyms:N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

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Technology Process of N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

There total 5 articles about N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.5%

: 1242163-43-4
C₂₀H₂₁N₃O₄S₂

: 1242163-33-2
N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 - 40 ℃; for 1.5h; pH=10; Reflux;
DOI:10.1039/c3ob41936c

Reference yield:

: 59-88-1
phenylhydrazine hydrochloride

: 1242163-33-2
N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; ethanol / 5 h / Reflux

2.1: triethylamine / acetone / 2 h / Reflux

3.1: sodium hydroxide / methanol / 2 h / Reflux

4.1: potassium carbonate / acetone / 0.5 h / 50 °C

4.2: 3 h / Reflux

5.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1.5 h / 20 - 40 °C / pH 10 / Reflux

With hydrogenchloride; hydroxylamine hydrochloride; potassium carbonate; triethylamine; potassium hydroxide; sodium hydroxide; In methanol; ethanol; water; acetone;
DOI:10.1039/c3ob41936c

Reference yield:

: 645-48-7
1-phenyl-3-thiosemicarbazide

: 1242163-33-2
N-hydroxy-3-(5-(4-(methylsulfonyl)phenyl)-1-phenyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetone / 2 h / Reflux

2.1: sodium hydroxide / methanol / 2 h / Reflux

3.1: potassium carbonate / acetone / 0.5 h / 50 °C

3.2: 3 h / Reflux

4.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1.5 h / 20 - 40 °C / pH 10 / Reflux

With hydroxylamine hydrochloride; potassium carbonate; triethylamine; potassium hydroxide; sodium hydroxide; In methanol; acetone;
DOI:10.1039/c3ob41936c