N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

Base Information

Chemical Name:N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide
CAS No.:214485-16-2
Molecular Formula:C₂₆H₁₇ClN₄OS
Molecular Weight:468.966
Hs Code.:

Synonyms:N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

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Chemical Property of N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

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Technology Process of N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

There total 5 articles about N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 590-93-2
2-Butynoic acid

: 214485-17-3
6-amino-4-[(3-chloro-4-thiophenoxy)phenylamino]-quinoline-3-carbonitrile

: 214485-16-2
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

Guidance literature:: 2-Butynoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 0.166667h;

6-amino-4-[(3-chloro-4-thiophenoxy)phenylamino]-quinoline-3-carbonitrile; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 25 ℃;

Reference yield:

: 214470-35-6,2305-65-9
6-nitro-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

: 214485-16-2
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 5.5 h / Heating / reflux

2.1: ethanol / 8 h / Heating / reflux

3.1: ethanol; tin(ll) chloride / 2 h / Heating / reflux

3.2: 2 h

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

4.2: 0 - 25 °C

With 4-methyl-morpholine; ethanol; tin(ll) chloride; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; ethanol;

Reference yield:

: 2458-24-4
2-cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester

: 214485-16-2
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-butynamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenyl ether-biphenyl eutectic / 12.5 h / 260 °C

2.1: trichlorophosphate / 5.5 h / Heating / reflux

3.1: ethanol / 8 h / Heating / reflux

4.1: ethanol; tin(ll) chloride / 2 h / Heating / reflux

4.2: 2 h

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / 0 °C

5.2: 0 - 25 °C

With 4-methyl-morpholine; diphenyl ether-biphenyl eutectic; ethanol; tin(ll) chloride; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; ethanol;