N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

Base Information

Chemical Name:N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide
CAS No.:867297-39-0
Molecular Formula:C₂₅H₂₇NO₄S
Molecular Weight:437.56
Hs Code.:

Synonyms:N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

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Chemical Property of N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

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Technology Process of N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

There total 4 articles about N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 942509-54-8
N-[(1S)-1-isopropylbuta-2,3-dienyl]-4-methyl-N-(prop-2-ynyl)phenylsulfonamide

: 619-44-3
methyl 4-iodobenzoate

: 867297-39-0
N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

Guidance literature:: With diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1021/jo0700528

Reference yield:

: 405932-52-7
N-[(1S)-1-isopropylbuta-2,3-dienyl]-4-methylphenylsulfonamide

: 867297-39-0
N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaH / dimethylformamide / 1 h / 0 °C

2: 65 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂; CuI / tetrahydrofuran / 6 h / 0 °C

With sodium hydride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1021/jo0700528

Reference yield:

: C₇H₁₃N

: 867297-39-0
N-[(1S)-1-isopropylbuta-2,3-dienyl]-N-[3-(4-methoxycarbonylphenyl)prop-2-ynyl]-4-methylphenylsulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 71.1 mg / Et₃N / CHCl₃ / 2 h / 20 °C

2: 70 percent / NaH / dimethylformamide / 1 h / 0 °C

3: 65 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂; CuI / tetrahydrofuran / 6 h / 0 °C

With sodium hydride; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 3: Sonogashira cross-coupling;
DOI:10.1021/jo0700528