2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

Base Information

Chemical Name:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one
CAS No.:1616289-36-1
Molecular Formula:C₂₄H₂₁BrCl₂N₂O₂
Molecular Weight:520.253
Hs Code.:

Synonyms:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

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Chemical Property of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

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Technology Process of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

There total 14 articles about 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1303445-99-9
2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine

: 1616289-35-0
7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one

: 1616289-36-1
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

Guidance literature:: 7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one; With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00515

Reference yield:

: 721959-71-3
2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

: 1616289-36-1
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

3.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 0 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; thionyl chloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1306439-42-8
[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methanol

: 1616289-36-1
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-7-bromo-5,8-dichloro-3,4-dihydroiso-quinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;