(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

Base Information

Chemical Name:(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate
CAS No.:1449786-52-0
Molecular Formula:C₂₁H₂₆N₄O₄
Molecular Weight:398.462
Hs Code.:

Synonyms:(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

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Chemical Property of (S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

There total 5 articles about (S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449786-46-2
(S)-methyl 2-(4-amino-3-((S)-2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzamido)propanoate

: 1449786-52-0
(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 36692-49-6
Methyl 3,4-diaminobenzoate

: 1449786-52-0
(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C / Inert atmosphere

2: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024

Reference yield:

: 1449786-44-0
(S)-methyl 4-amino-3-(2-(tert-butoxycarbonylamino)-4-phenylbutanamido)benzoate

: 1449786-52-0
(S)-methyl 2-(4-amino-3-((S)-2-amino-4-phenylbutanamido)benzamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / 1,4-dioxane; water / 4 h / 25 °C / Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 25 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.024