9',9'-diphenyldimethylcyclolariciresinol

Base Information

• Chemical Name: 9',9'-diphenyldimethylcyclolariciresinol
• CAS No.: 1403982-14-8
• Molecular Formula: C₃₄H₃₆O₆
• Molecular Weight: 540.656
• Mol file: 1403982-14-8.mol

Synonyms:9',9'-diphenyldimethylcyclolariciresinol

Chemical Property of 9',9'-diphenyldimethylcyclolariciresinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9',9'-diphenyldimethylcyclolariciresinol

There total 3 articles about 9',9'-diphenyldimethylcyclolariciresinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phenyllithium (591-51-5) + α-conidendrin dimethyl ether (71772-18-4) → 9',9'-diphenyldimethylcyclolariciresinol (1403982-14-8)

Guidance literature:

In tetrahydrofuran; dibutyl ether; at -78 ℃; for 2.33333h;

DOI:10.1016/j.tetlet.2012.12.066

Reference yield:

(7RS,8R,8'R)-4,4',7-trihydroxy-3,3'-dimethoxylignano-9,9'-lactone (347359-71-1) → 9',9'-diphenyldimethylcyclolariciresinol (1403982-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / 0.16 h

2: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3: tetrahydrofuran; dibutyl ether / 2.33 h / -78 °C

With formic acid; potassium carbonate; In tetrahydrofuran; dibutyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.12.066

Reference yield:

conidendrin (518-55-8,5474-93-1,22614-13-7,26358-20-3,85699-62-3,89104-61-0,105817-20-7) → 9',9'-diphenyldimethylcyclolariciresinol (1403982-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2: tetrahydrofuran; dibutyl ether / 2.33 h / -78 °C

With potassium carbonate; In tetrahydrofuran; dibutyl ether; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.12.066

upstream raw materials:

phenyllithium

α-conidendrin dimethyl ether

(7RS,8R,8'R)-4,4',7-trihydroxy-3,3'-dimethoxylignano-9,9'-lactone

conidendrin

Downstream raw materials:

9',9'-diphenyldimethylretrodendrin

9-O-benzyl-9',9'-diphenyldimethylcyclolariciresinol

9’-O-methyl-9-O-benzyl-9',9'-diphenyldimethylcyclolariciresinol

9’-O-methyl-9',9'-diphenyl-dimethylcyclolariciresinol