tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Base Information

Chemical Name:tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
CAS No.:1345014-04-1
Molecular Formula:C₁₉H₂₁N₃O₃S
Molecular Weight:371.46
Hs Code.:

Synonyms:tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

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Chemical Property of tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

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Technology Process of tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

There total 1 articles about tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1345013-92-4
tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate

: 1670-14-0
benzamidine monohydrochloride

: 1345014-04-1
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Guidance literature:: benzamidine monohydrochloride; With sodium hydride; In N,N-dimethyl-formamide; toluene; mineral oil; for 0.0833333h;

tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate; In N,N-dimethyl-formamide; toluene; mineral oil; at 100 ℃; for 48h;
DOI:10.1021/acs.jmedchem.7b01751

Reference yield:

: 1345014-04-1
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 1345014-20-1
4-(methylsulfonyl)-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 - 20 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.7b01751

Reference yield:

: 1345014-04-1
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 1345014-74-5
4-[(3-methoxyphenyl)amino]-2-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 5 - 20 °C

2: ethanol / 9 h / 160 °C / Microwave irradiation

With 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b01751