(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

Base Information

Chemical Name:(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide
CAS No.:1434517-06-2
Molecular Formula:C₂₂H₁₅ClF₃N₃O₃
Molecular Weight:461.828
Hs Code.:

Synonyms:(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

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Technology Process of (S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

There total 5 articles about (S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1434518-37-2
C₁₀H₈ClF₃O₃

: 349609-85-4
5-amino-2-(pyridine-4-yl)benzo[d]oxazole

: 1434517-06-2
(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm400241j

Reference yield: 70.0%

: 1434517-06-2
(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 99-57-0
2-hydroxy-5-nitroaniline

: 1434517-06-2
(S)-2-(2-chloro-3-(trifluoromethyl)phenoxy)-N-(2-(pyridine-4-yl)benzo[d]oxazol-5-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxygen; pyrographite / 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 120 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 6 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; oxygen; pyrographite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm400241j