4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

Base Information

Chemical Name:4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide
CAS No.:376584-00-8
Molecular Formula:C₁₇H₁₆N₄O₂
Molecular Weight:308.34
Hs Code.:

Synonyms:4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

Chemical Property:

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Technology Process of 4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

There total 19 articles about 4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 645058-32-8
[5-(4-carbamoyl-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 376584-00-8
4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2003.07.031

Reference yield: 80.0%

: 376584-00-8
4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

Guidance literature:

Reference yield:

: 85-91-6
Methyl N-methylanthranilate

: 376584-00-8
4-(3-amino-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide

Guidance literature:: Multi-step reaction with 15 steps

1: CH₂Cl₂

2: aq. NaOH / 0 °C

3: NH₃ / methanol

4: NaH / tetrahydrofuran

5: Mg; I₂ / tetrahydrofuran

6: HCl / ethyl acetate

7: iAmONO; tBuOK / toluene

8: Et₃N / tetrahydrofuran

9: H₂ / Pd/C / methanol

10: aq. Na₂CO₃ / dioxane

11: HCl / dioxane

12: Et₃N / CH₂Cl₂

13: aq. NaOH / tetrahydrofuran

14: NH₄Cl; EDC; HOBt / dimethylformamide

15: HBr; AcOH

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; ammonia; hydrogen bromide; hydrogen; iodine; sodium hydride; sodium carbonate; ammonium chloride; benzotriazol-1-ol; magnesium; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; isopentyl nitrite; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(02)00909-5