Technology Process of 6-nitro-4-(phenylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide
There total 7 articles about 6-nitro-4-(phenylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium hydroxide; dihydrogen peroxide;
In
ethanol; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -10 °C
1.2: 20 h / 20 °C
2.1: hydrogenchloride / ethanol; water / 15 h / Reflux
2.2: 1 h / 80 °C
2.3: pH 1
3.1: N,N-diethylaniline; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 1 h / 80 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C
5.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 20 °C
With
hydrogenchloride; ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: nitric acid / acetic anhydride; water / 4 h / -40 - 20 °C
2.1: methanol / 2 h / 20 °C
3.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -10 °C
3.2: 20 h / 20 °C
4.1: hydrogenchloride / ethanol; water / 15 h / Reflux
4.2: 1 h / 80 °C
4.3: pH 1
5.1: N,N-diethylaniline; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 1 h / 80 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C
7.1: ammonium hydroxide; dihydrogen peroxide / ethanol; water / 20 °C
With
hydrogenchloride; ammonium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; nitric acid; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; lithium hexamethyldisilazane; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; water; acetic anhydride; N,N-dimethyl-formamide; acetonitrile;