Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

Base Information

Chemical Name:Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide
CAS No.:117523-75-8
Molecular Formula:C₂₅H₂₅N₃O₃
Molecular Weight:415.492
Hs Code.:

Synonyms:Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

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Chemical Property of Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

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Technology Process of Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

There total 4 articles about Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 527-69-5
2-furancarbonyl chloride

: 104588-08-1
Benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amine

: 117523-75-8
Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

Guidance literature:: With triethylamine; In chloroform; for 0.5h; Ambient temperature;
DOI:10.1021/jm00123a028

Reference yield:

: 615-18-9
2-chloro-1,3-benzoxazole

: 117523-75-8
Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / 3-methyl-butan-1-ol / Heating

2: 85 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With sodium carbonate; triethylamine; In i-Amyl alcohol; chloroform;
DOI:10.1021/jm00123a028

Reference yield:

: 79278-71-0
1-phenethylpiperidin-4-one oxime

: 117523-75-8
Furan-2-carboxylic acid benzooxazol-2-yl-(1-phenethyl-piperidin-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: Na₂CO₃ / 3-methyl-butan-1-ol / Heating

3: 85 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; sodium carbonate; triethylamine; In tetrahydrofuran; i-Amyl alcohol; chloroform;
DOI:10.1021/jm00123a028