3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

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Chemical Name:3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine
CAS No.:1261071-61-7
Molecular Formula:C₂₈H₂₈N₈
Molecular Weight:476.584
Hs Code.:

Synonyms:3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

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Chemical Property of 3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

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Technology Process of 3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

There total 12 articles about 3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261072-21-2
tert-butyl (2S)-2-(5-[7-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridin-3-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261071-61-7
3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 75 ℃; for 1.5h;

Reference yield:

: 1179149-96-2
tert-butyl (2S)-2-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261071-61-7
3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane; ethanol / 1.5 h / 75 °C

With hydrogenchloride; N-Bromosuccinimide; TurboGrignard; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261071-61-7
3-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-7-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 16 h / 20 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / microwave irradiation

6.1: hydrogenchloride / 1,4-dioxane; ethanol / 1.5 h / 75 °C

With hydrogenchloride; sodium hypochlorite; N-Bromosuccinimide; TurboGrignard; sodium hydride; sodium hydrogencarbonate; sodium carbonate; sodium bromide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;