S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester

Base Information

• Chemical Name: S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester
• CAS No.: 1011302-70-7
• Molecular Formula: C₃₁H₂₆INO₄
• Molecular Weight: 603.456
• Mol file: 1011302-70-7.mol

Synonyms:S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester

Chemical Property of S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester

There total 1 articles about S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C16H16INO2 (1011302-62-7) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester (1011302-70-7)

Guidance literature:

With N-ethylmorpholine;; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1080/00397910701771090

Reference yield: 50.0%

S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester (1011302-70-7) + N-(tert-butoxycarbonyl)-D-alanine methyl ester (91103-47-8) → 2S,2R-3-[2-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester (1011302-72-9)

Guidance literature:

N-(tert-butoxycarbonyl)-D-alanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 0 ℃; for 1.16667h;

S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester; dichlorobis(tri-O-tolylphosphine)palladium; In N,N-dimethyl-formamide; for 4.5h; Further stages.;

DOI:10.1080/00397910701771090

Reference yield: 47.0%

S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester (1011302-70-7) + (S)-N-(tert-butoxycarbonyl)alanine methyl ester (28875-17-4) → 2S,2S-3-[2-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester (1011302-71-8)

Guidance literature:

(S)-N-(tert-butoxycarbonyl)alanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 0 ℃; for 1.16667h;

S-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-iodo-phenyl)-propionic acid benzyl ester; dichlorobis(tri-O-tolylphosphine)palladium; In N,N-dimethyl-formamide; for 4.5h; Further stages.;

DOI:10.1080/00397910701771090

upstream raw materials:

C₁₆H₁₆INO₂

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

2S,2S-3-[2-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester

2S,2R-3-[2-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester