3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

Base Information

Chemical Name:3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate
CAS No.:249286-79-1
Molecular Formula:C₂₃H₂₆N₃O₁₁P
Molecular Weight:551.447
Hs Code.:

Synonyms:3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

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Chemical Property of 3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

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Technology Process of 3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

There total 2 articles about 3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 96-35-5
glycolic acid methyl ester

: 249286-78-0
3'-O-benzoyl-thymidine 5'-<(2-cyanoethyl)-N,N'-diisopropyl> phosphoramidite

: 249286-79-1
3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

Guidance literature:: With 1H-tetrazole; tert.-butylhydroperoxide; In acetonitrile; for 1.5h;
DOI:10.1016/S0008-6215(99)00074-9

Reference yield:

: 107180-53-0
3'-O-benzoyl-5'-O-p-toluenesulfonyl-thymidine

: 249286-79-1
3'-O-benzoyl-thymidine 5'-(2-cyanoethyl)-methoxycarbonylmethyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / N,N-diisopropylethylamine / acetonitrile / 0.5 h

2: 80 percent / 1-H tetrazole; tert-butylyhydroperoxide / acetonitrile / 1.5 h

With 1H-tetrazole; tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; In acetonitrile; 1: Substitution / 2: Substitution;
DOI:10.1016/S0008-6215(99)00074-9