3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel

Base Information

• Chemical Name: 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel
• CAS No.: 170241-02-8
• Molecular Formula: C₃₆H₄₉NO₁₂
• Molecular Weight: 687.785
• Mol file: 170241-02-8.mol

Synonyms:3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel

Chemical Property of 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel

There total 4 articles about 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel (170241-01-7) → 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel (170241-02-8)

Guidance literature:

With acetic acid; zinc; In methanol; at 60 ℃; for 2h;

DOI:10.1021/jm960505t

Reference yield:

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III (95603-44-4) → 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel (170241-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

3: 0.15 g / Zn, AcOH / methanol / 2 h / 60 °C

With dmap; formic acid; acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; toluene;

DOI:10.1021/jm00019a012

Reference yield:

(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid (170240-99-0) → 3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenylpaclitaxel (170241-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 1,3-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / toluene / a) 60 deg C, 20 h, b) 85 deg C, 4 h

2: 62 percent / 90percent HCOOH / 24 h / Ambient temperature

3: 0.15 g / Zn, AcOH / methanol / 2 h / 60 °C

With dmap; formic acid; acetic acid; dicyclohexyl-carbodiimide; zinc; In methanol; toluene;

DOI:10.1021/jm00019a012

upstream raw materials:

3'-tert-butyl-10-deacetyl-N-debenzoyl-3'-dephenyl-7,10-bis<<(2,2,2-trichloroethyl)oxy>carbonyl>paclitaxel

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

(4S,5R)-3-(tert-butoxycarbonyl)-4-tert-butyl-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid