Technology Process of ethyl 2-benzyl-pent-4-ynoate
There total 1 articles about ethyl 2-benzyl-pent-4-ynoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl dihydrocinnamate;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
propargyl bromide;
In
tetrahydrofuran; hexane; toluene;
at -78 - 25 ℃;
for 3h;
DOI:10.1021/ja053462r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1.05 g / LiAlH4 / diethyl ether / 0.5 h / 0 °C
2.1: 95 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -78 - 25 °C
3.1: NaH / tetrahydrofuran / 0.17 h / 0 - 25 °C
3.2: tetrahydrofuran / 1.5 h / 25 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja053462r
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.05 g / LiAlH4 / diethyl ether / 0.5 h / 0 °C
2: 95 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH2Cl2 / -78 - 25 °C
3: 31 percent / toluene / 48 h / Heating
With
lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja053462r
