(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Base Information

Chemical Name:(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester
CAS No.:1400704-35-9
Molecular Formula:C₂₆H₃₁N₅O₅S
Molecular Weight:525.629
Hs Code.:

(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Synonyms:(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

There total 10 articles about (S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: C₂₁H₂₉N₅O₄*ClH

: 1400704-35-9
(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 168130-75-4
4,6-dimethyl-2-hydroxypyrimidine-5-carboxylic acid ethyl ester

: 1400704-35-9
(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 110 °C

2.1: ethanol / 1 h / 160 °C / microwave irradiation

2.2: 20 °C

3.1: triethylamine / Schwartz's reagent / tetrahydrofuran / 20.3 h / 150 °C / microwave irradiation

4.1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene / tetrahydrofuran / 24 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr / H-Cube

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 90 °C

6.2: 20 °C / pH ~ 2 - 4

7.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

8.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

9.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; Schwartz's reagent; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 108381-23-3
2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

: 1400704-35-9
(S)-2-({2-[3-(2-methyl-5-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 1 h / 160 °C / microwave irradiation

1.2: 20 °C

2.1: triethylamine / Schwartz's reagent / tetrahydrofuran / 20.3 h / 150 °C / microwave irradiation

3.1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene / tetrahydrofuran / 24 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr / H-Cube

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 90 °C

5.2: 20 °C / pH ~ 2 - 4

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

8.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; Schwartz's reagent; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;