{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

Base Information

Chemical Name:{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone
CAS No.:380239-25-8
Molecular Formula:C₂₇H₂₁F₂NO₄
Molecular Weight:461.465
Hs Code.:

Synonyms:{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

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Chemical Property of {4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

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Technology Process of {4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

There total 4 articles about {4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 58113-36-3
4-(bis(4-fluorophenyl)methylene)piperidine

: 380239-19-0
6-hydroxy-1,4-benzodioxin-2-carboxylic acid

: 380239-25-8
{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm0108045

Reference yield:

: 75286-86-1
6-Acetyl-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid ethyl ester

: 380239-25-8
{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 79 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / 40 °C

2.1: N-bromosuccinimide; AIBN / CCl₄ / 3 h / Heating

2.2: 97 percent / NaI / acetone / 4 h / 20 °C

3.1: 87 percent / 10percent aq. NaOH / ethanol / 4 h / 20 °C

4.1: 80 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 18 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Baeyer-Villiger oxidation;
DOI:10.1021/jm0108045

Reference yield:

: 160657-88-5
6-acetoxy-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid ethyl ester

: 380239-25-8
{4-[bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-(6-hydroxy-benzo[1,4]dioxin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-bromosuccinimide; AIBN / CCl₄ / 3 h / Heating

1.2: 97 percent / NaI / acetone / 4 h / 20 °C

2.1: 87 percent / 10percent aq. NaOH / ethanol / 4 h / 20 °C

3.1: 80 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 18 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0108045