(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Base Information

Chemical Name:(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one
CAS No.:1207362-50-2
Molecular Formula:C₁₆H₁₈Cl₃NO₃
Molecular Weight:378.683
Hs Code.:

Synonyms:(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Suppliers and Price of (S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

There total 3 articles about (S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 75-62-7
Bromotrichloromethane

: 168297-93-6
(S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one

: 1207362-50-2
(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one; With titanium tetrachloride; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.666667h; Inert atmosphere;

Bromotrichloromethane; With tris(triphenylphosphine)ruthenium(II) chloride; In dichloromethane; at 45 ℃; for 12h; optical yield given as %de; Inert atmosphere; Sealed vial;
DOI:10.1021/ja910154f

Reference yield:

: 168297-85-6,352438-06-3
(S)-4-benzyl-5,5-dimethyloxazolidin-2-one

: 1207362-50-2
(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

2.2: 0.75 h / 0 °C / Inert atmosphere

2.3: 12 h / Inert atmosphere

With n-butyllithium; titanium tetrachloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/asia.201100338

Reference yield:

: 75-62-7
Bromotrichloromethane

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 168297-93-6
(S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one

: 1207362-58-0
C₁₄H₁₄Cl₃NO₃

: 1207362-50-2
(S)-4-benzyl-5,5-dimethyl-3-((S)-3,3,3-trichloro-2-methylpropanoyl)-oxazolidin-2-one

Guidance literature:: (S)-4-benzyl-5,5-dimethyl-3-propanoyl-1,3-oxazolidin-2-one; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.75h; Inert atmosphere;

(S)-4-benzyl-3-propionyl-2-oxazolidinone; In dichloromethane; at 0 ℃; for 0.75h; Inert atmosphere;

Bromotrichloromethane; With tris(triphenylphosphine)ruthenium(II) chloride; In dichloromethane; at 45 ℃; for 20h; Inert atmosphere;
DOI:10.1002/anie.201101364