(S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine

Base Information

• Chemical Name: (S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine
• CAS No.: 1438883-34-1
• Molecular Formula: C₂₀H₁₈ClN₅S
• Molecular Weight: 395.915

Synonyms:(S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine

Chemical Property of (S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine

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Technology Process of (S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine

There total 3 articles about (S)-N₁-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-4-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidine (1438887-60-5) + (S)-2-(t-butoxycarbonylamino)-3-phenylpropylamine (146552-72-9,179051-72-0) → (S)-N1-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine (1438883-34-1)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 18h;

Reference yield:

7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol (1438887-42-3) → (S)-N1-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine (1438883-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 48 h / 80 °C

2: triethylamine / N,N-dimethyl acetamide / 18 h / 20 °C

With triethylamine; trichlorophosphate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol (214417-12-6) → (S)-N1-(7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-phenylpropane-l,2-diamine (1438883-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; N-chloro-succinimide / 42 h / 80 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 48 h / 80 °C

3: triethylamine / N,N-dimethyl acetamide / 18 h / 20 °C

With N-chloro-succinimide; acetic acid; triethylamine; trichlorophosphate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol

7-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-ol

7-chloro-4-chloro-2-pyridin-4-ylthieno[3,2-d]pyrimidine

(S)-2-(t-butoxycarbonylamino)-3-phenylpropylamine

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