Technology Process of (3Z,5E)-1-[(4R,6S)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]-4-hydroxy-6-phenylhexa-3,5-dien-2-one
There total 7 articles about (3Z,5E)-1-[(4R,6S)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]-4-hydroxy-6-phenylhexa-3,5-dien-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-iodoxybenzoic acid;
In
acetone;
at 20 - 50 ℃;
for 4h;
DOI:10.1021/ol400232m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / diethyl ether / 4 h / 0 - 20 °C / Inert atmosphere
2.1: copper(l) iodide / tetrahydrofuran / 2.5 h / -78 - -10 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / 0.5 h / 20 °C / Inert atmosphere
4.1: palladium dichloride; copper(l) chloride; oxygen / N,N-dimethyl-formamide; water
5.1: triethylamine; di-n-butylboryl trifluoromethanesulfonate / diethyl ether / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 2.17 h / -78 °C / Inert atmosphere
6.1: 2-iodoxybenzoic acid / acetone / 4 h / 20 - 50 °C
With
copper(l) iodide; 2-iodoxybenzoic acid; di-n-butylboryl trifluoromethanesulfonate; oxygen; toluene-4-sulfonic acid; triethylamine; copper(l) chloride; potassium hydroxide; palladium dichloride;
In
tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetone;
4.1: |Wacker Oxidation;
DOI:10.1021/ol400232m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; di-n-butylboryl trifluoromethanesulfonate / diethyl ether / 0.5 h / -78 - 20 °C / Inert atmosphere
1.2: 2.17 h / -78 °C / Inert atmosphere
2.1: 2-iodoxybenzoic acid / acetone / 4 h / 20 - 50 °C
With
2-iodoxybenzoic acid; di-n-butylboryl trifluoromethanesulfonate; triethylamine;
In
diethyl ether; acetone;
DOI:10.1021/ol400232m