ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate
• CAS No.: 1357010-86-6
• Molecular Formula: C₂₀H₂₁ClN₂O₂
• Molecular Weight: 356.852

Synonyms:ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Chemical Property of ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

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Technology Process of ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

There total 3 articles about ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 4-hydroxy-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-80-0) → ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-86-6)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In tetrahydrofuran; for 2.5h; Reflux;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

3-(2,4-dimethyl-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester (63131-39-5) → ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 36 h / Reflux

2: tetrachloromethane; triphenylphosphine / tetrahydrofuran / 2.5 h / Reflux

With tetrachloromethane; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmc.2011.11.015

Reference yield:

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate (941693-86-3) → ethyl 4-chloro-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate (1357010-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 36 h / Reflux

2: tetrachloromethane; triphenylphosphine / tetrahydrofuran / 2.5 h / Reflux

With tetrachloromethane; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmc.2011.11.015

upstream raw materials:

ethyl 4-hydroxy-2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

Ethyl 1-amino-5-methyl-1H-pyrrole-3-carboxylate

3-(2,4-dimethyl-phenyl)-2-methyl-3-oxo-propionic acid ethyl ester

Downstream raw materials:

ethyl 2-(2,4-dimethylphenyl)-3,7-dimethylpyrrolo[1,2-b]pyridazine-5-carboxylate

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