2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

Base Information

Chemical Name:2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline
CAS No.:125439-25-0
Molecular Formula:C₂₀H₂₃N₅O₂
Molecular Weight:365.435
Hs Code.:

Synonyms:2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

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Technology Process of 2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

There total 2 articles about 2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125439-51-2
4-<4-(1,2,3,4-tetrahydroquinolin-2-ylmethoxy)phenoxy>-butyronitrile

: 125439-25-0
2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 140 ℃; for 18h;
DOI:10.1021/jm00166a016

Reference yield:

: 40232-83-5
4-(4-hydroxyphenoxy)butanenitrile

: 125439-25-0
2-{4-[3-(1H-Tetrazol-5-yl)-propoxy]-phenoxymethyl}-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 50percent aq. NaOH / dimethylsulfoxide / 1.5 h / 40 - 60 °C

2: 0.6 g / H₂ / 10percent Pd/C / ethanol / 4 h / 2068.6 Torr

3: sodium azide, NH₄Cl / dimethylformamide / 18 h / 140 °C

With sodium hydroxide; sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00166a016