4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Base Information

Chemical Name:4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide
CAS No.:943771-13-9
Molecular Formula:C₂₉H₂₅BrN₆OS
Molecular Weight:585.527
Hs Code.:

Synonyms:4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

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Chemical Property of 4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

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Technology Process of 4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

There total 12 articles about 4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester

: 943771-13-9
4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: {4-[4-(4-bromo-phenylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 329941-08-4
N-(4-bromo-phenyl)-4-chloro-3-nitro-benzamide

: 943771-13-9
4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 90 °C

1.2: pH 5

2.1: 1,4-dioxane / 10.5 h / Heating / reflux

3.1: iron; ammonium chloride / ethanol; water / 1 h / 90 °C

4.1: acetic acid / 0.25 h / 140 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With iron; ammonium chloride; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 943771-13-9
4-(4-amino-phenylsulfanyl)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / diethyl ether / 0 - 20 °C

2.1: water / 0.17 h / 20 °C

2.2: 2 h / Heating / reflux

2.3: pH 4

3.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux

4.1: ammonia / ethanol / 20 h / 130 °C

5.1: toluene / 3 h / Heating / reflux

6.1: acetic acid / 0.25 h / 140 °C

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With tetrabutylammomium bromide; ammonia; sodium; phosphorus pentoxide; trifluoroacetic acid; In diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;