((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Base Information

Chemical Name:((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate
CAS No.:1034401-91-6
Molecular Formula:C₂₃H₃₇NO₅
Molecular Weight:407.55
Hs Code.:

Synonyms:((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Suppliers and Price of ((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

There total 9 articles about ((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1034401-88-1
((2S,3R,4S)-1-(tert-butyldimethylsilyloxy)-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

: 1034401-91-6
((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield:

: (2R,3R,4S,5S)-6-(4-Methoxy-benzyloxy)-3,5-dimethyl-hexane-1,2,4-triol

: 1034401-91-6
((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium periodate / tetrahydrofuran; water / 2 h / 0 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr

4.1: 1H-imidazole / tetrahydrofuran / 8 h / 0 °C

5.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 0 - 20 °C

6.1: camphor-10-sulfonic acid / methanol; dichloromethane / 0.5 h / 0 °C

With 1H-imidazole; dmap; sodium periodate; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1016/j.tetasy.2013.07.012

Reference yield:

: C₂₀H₃₂O₃

: 1034401-91-6
((2S,3R,4S)-1-hydroxy-2,4-dimethyldecan-3-yl) (S)-2-(benzyloxycarbonylamino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr

2: 1H-imidazole / tetrahydrofuran / 8 h / 0 °C

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 0 - 20 °C

4: camphor-10-sulfonic acid / methanol; dichloromethane / 0.5 h / 0 °C

With 1H-imidazole; dmap; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetasy.2013.07.012