5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole
CAS No.:1415904-92-5
Molecular Formula:C₂₂H₃₄N₄O₄SSi
Molecular Weight:478.688
Hs Code.:

Synonyms:5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

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Chemical Property of 5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

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Technology Process of 5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

There total 1 articles about 5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 188127-20-0
((3aS,4S,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 1415904-92-5
5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1016/j.tetasy.2012.10.010

Reference yield: 70.0%

: 1415904-92-5
5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

: 1415904-89-0
5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol; at 0 - 20 ℃; for 12.1667h;
DOI:10.1016/j.tetasy.2012.10.010

Reference yield:

: 1415904-92-5
5-(((3aR,4R,6R,6aR)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methylthio)-1-phenyl-1H-tetrazole

: 1415904-93-6
C₂₅H₃₈O₇Si

: 1415904-96-9
C₂₅H₃₈O₇Si

Guidance literature:: Multi-step reaction with 2 steps

1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol / 12.17 h / 0 - 20 °C

2: lithium hexamethyldisilazane / 1,2-dimethoxyethane / 13.25 h / -78 - 20 °C

With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; lithium hexamethyldisilazane; In 1,2-dimethoxyethane; ethanol; 2: |Julia-Kocienski Olefination;
DOI:10.1016/j.tetasy.2012.10.010