Chemical Property of (3R,5R)-3,4,5,6-tetrahydroxyhexanal
Chemical Property:
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:1.8E-08mmHg at 25°C
- Melting Point:146-147 °C(lit.)
- Refractive Index:46.5 ° (C=1, H2O)
- Boiling Point:411 °C at 760 mmHg
- PKA:pK1:12.52 (25°C)
- Flash Point:202.3 °C
- PSA：97.99000
- Density:1.533 g/cm3
- LogP:-2.34960
- Storage Temp.:0-6°C
- Solubility.:H2O: 50 mg/mL, clear, colorless to faintly yellow
- Water Solubility.:Soluble in water.
- XLogP3:-2.9
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:164.06847348
- Heavy Atom Count:11
- Complexity:116
- Purity/Quality:
-
99% *data from raw suppliers
2-Deoxy-D-glucose 98+% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xn,Xi
- Statements:
20/21/22-36/37/38
- Safety Statements:
24/25-37/39-36-26
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C(C=O)C(C(C(CO)O)O)O
- Isomeric SMILES:C(C=O)[C@H](C([C@@H](CO)O)O)O
- Recent ClinicalTrials:Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy
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Description
2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, which inhibits hexokinase and phosphoglucose-isomerase leading to decreased ATP production, cell cycle blockage, decreased cell growth and ultimately cell death.1,2
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Uses
2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis. This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response. 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.[Cayman Chemical] 2-Deoxy-D-glucose is act as a culture media part in molecular genetics and as a targeted optical imaging agent for fluorescent in vivo imaging. It finds an application in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). It is utilized in the development of anti-cancer approaches like oxidative stress, radio and chemosensitization. 2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
