4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate

Base Information

• Chemical Name: 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate
• CAS No.: 1610737-86-4
• Molecular Formula: C₂₆H₂₀O₉S
• Molecular Weight: 508.505
• Mol file: 1610737-86-4.mol

Synonyms:4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate

Chemical Property of 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate

There total 3 articles about 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(5-acetoxy-7-hydroxy-4-oxo-4H-chromen-3-yl)phenyl acetate (23050-36-4) + p-toluenesulfonyl chloride (98-59-9) → 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate (1610737-86-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2014.04.016

Reference yield:

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on (446-72-0) → 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate (1610737-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 6 h / 70 °C

2: thiophenol; 1H-imidazole / 1-methyl-pyrrolidin-2-one / 2 h / 0 - 20 °C

3: triethylamine / tetrahydrofuran / 8 h / 20 °C

With pyridine; 1H-imidazole; thiophenol; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

DOI:10.1016/j.bmc.2014.04.016

Reference yield:

4',5,7-Triacetoxyisoflavone (5995-97-1) → 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-3-yl)phenyl acetate (1610737-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thiophenol; 1H-imidazole / 1-methyl-pyrrolidin-2-one / 2 h / 0 - 20 °C

2: triethylamine / tetrahydrofuran / 8 h / 20 °C

With 1H-imidazole; thiophenol; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

DOI:10.1016/j.bmc.2014.04.016

upstream raw materials:

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

4',5,7-Triacetoxyisoflavone

4-(5-acetoxy-7-hydroxy-4-oxo-4H-chromen-3-yl)phenyl acetate

p-toluenesulfonyl chloride

Downstream raw materials:

5-hydroxy-3-(4-hydroxyphenyl)-7-morpholino-4H-chromen-4-one

5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

5-(benzyloxy)-3-(4-(benzyloxy)phenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate

5-(benzyloxy)-3-(4-(benzyloxy)phenyl)-7-morpholino-4H-chromen-4-one