N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Base Information

Chemical Name:N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride
CAS No.:1124219-53-9
Molecular Formula:C₂₅H₂₅FN₂O₂*ClH
Molecular Weight:440.945
Hs Code.:

Synonyms:N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

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Chemical Property of N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Chemical Property:

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Technology Process of N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

There total 5 articles about N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₃FN₂O₄

: 1124219-53-9
N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In chloroform; at 0 ℃;
DOI:10.1021/jm801141f

Reference yield:

: 106-38-7
para-bromotoluene

: 1124219-53-9
N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / PEG₄₀₀ / 16 h / 110 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 20 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 4 h / 20 °C

4.1: hydrogenchloride / chloroform / 0.5 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; In tetrachloromethane; PEG₄₀₀; chloroform; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1016/j.ejps.2010.11.010

Reference yield:

: 72093-43-7
4-methyl-4'-fluorobiphenyl

: 1124219-53-9
N-{3-[(4'-fluoro-1,1'-biphenyl-4-yl)methoxy]phenyl}piperidine-4-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 20 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / chloroform / 0.5 h / 0 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrachloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.ejps.2010.11.010