11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

Base Information

Chemical Name:11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine
CAS No.:1388831-66-0
Molecular Formula:C₄₂H₃₄O₃
Molecular Weight:586.73
Hs Code.:

Synonyms:11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

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Chemical Property of 11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

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Technology Process of 11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

There total 3 articles about 11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: 2052-07-5
2-Bromobiphenyl

: 1384864-32-7
3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepin-11(5H)-one

: 1388831-66-0
11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

Guidance literature:: 2-Bromobiphenyl; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepin-11(5H)-one; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.3987/COM-12-12427

Reference yield:

: 485-47-2
indan-1,2,3-trione hydrate

: 1388831-66-0
11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol; ethanol / 3 h / 75 °C

2.1: 0.08 h / 240 °C

3.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / Reflux

4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; 2.1: Diels-Alder reaction;
DOI:10.3987/COM-12-12427

Reference yield:

: 6583-74-0
1,3-diphenylcyclopenta[a]indene-2,8-dione

: 1388831-66-0
11-hydroxy-11-(biphenyl-2-yl)-5,11-dihydro-3,3-dimethyl-6,12-diphenyl-1H-fluoreno[2,3-e][1,3]dioxepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.08 h / 240 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; 1.1: Diels-Alder reaction;
DOI:10.3987/COM-12-12427