2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester
• CAS No.: 359868-56-7
• Molecular Formula: C₃₀H₃₂N₂O₈
• Molecular Weight: 548.593
• Mol file: 359868-56-7.mol

Synonyms:2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester

Chemical Property of 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester

There total 2 articles about 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Cbz-(L)-Glu-OBn (3705-42-8) + L-serine benzyl ester hydrochloride (60022-62-0,879278-55-4,151651-44-4) → 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester (359868-56-7)

Guidance literature:

Cbz-(L)-Glu-OBn; L-serine benzyl ester hydrochloride; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;

L-serine benzyl ester hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/jm015509z

Reference yield:

Cbz-(L)-Glu-OBn (3705-42-8) + L-serine benzyl ester benzenesulfonate salt (3695-68-9) → 2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester (359868-56-7)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

Reference yield: 45.0%

2-benzyloxycarbonylamino-4-(1-benzyloxycarbonyl-2-hydroxyethylcarbamoyl)butyric acid benzyl ester (359868-56-7) → (2S,4'S)-2-benzyloxycarbonylamino-4-(4'-benzyloxycarbonyloxazolin-2-yl)butyric acid benzyl ester

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; at 1 ℃; Heating;

DOI:10.1021/jm015509z

upstream raw materials:

Cbz-(L)-Glu-OBn

L-serine benzyl ester benzenesulfonate salt

L-serine benzyl ester hydrochloride

Downstream raw materials:

C₃₇H₃₉N₂O₁₀P

C₅₆H₅₈N₃O₁₄P