N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

Base Information

Chemical Name:N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide
CAS No.:1396795-88-2
Molecular Formula:C₂₃H₁₇F₃N₂O₃
Molecular Weight:426.395
Hs Code.:

Synonyms:N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

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Chemical Property of N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

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Technology Process of N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

There total 5 articles about N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 863719-46-4
2-[5-bromo-2-oxo-1,3-benzoxazol-3(2H)-yl]-N-methyl-N-phenylacetamide

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1396795-88-2
N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; for 12h; Reflux;
DOI:10.1016/j.bmc.2012.07.023

Reference yield:

: 7693-52-9
4-bromo-2-nitrophenol

: 1396795-88-2
N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: Rh/C; hydrogen / tetrahydrofuran / 11 h / 20 °C

2: tetrahydrofuran / 2 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Cooling with ice

4: hydrogenchloride / acetic acid; 1,4-dioxane / 4 h / 50 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Rh/C; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.023

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1396795-88-2
N-methyl-2-{2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3-benzoxazol-3(2H)-yl}-N-phenylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Cooling with ice

3: hydrogenchloride / acetic acid; 1,4-dioxane / 4 h / 50 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.023